Is Breath Best? A Systematic Review on the Accuracy and Utility of Nanotechnology Based Breath Analysis of Ketones in Type 1 Diabetes

Is Breath Best? A Systematic Review on the Accuracy and Utility of Nanotechnology Based Breath Analysis of Ketones in Type 1 Diabetes

Blog Article

Timely ketone detection in patients with type 1 diabetes mellitus (T1DM) is critical for the effective management of diabetic ketoacidosis (DKA).This systematic review evaluates the current literature on breath-based analysis for ketone detection in T1DM, highlighting nanotechnology as a potential for a non-invasive alternative to blood-based ketone measurements.A comprehensive search across 5 databases identified 11 studies meeting inclusion criteria, showcasing various breath analysis techniques, such as semiconducting gas sensors, moen finney colorimetry, and nanoparticle-based chemo-resistive sensors.These studies report high sensitivity and correlation between breath acetone (BrAce) levels and blood ketones, ngetikin with some demonstrating accuracies up to 94.7% and correlations reaching R2 values as high as 0.

98.However, significant heterogeneity in methodologies and cut-off values limits device comparability and precludes meta-analysis.Despite these challenges, the findings indicate that BrAce monitoring could offer significant clinical benefits by enabling the earlier detection of ketone buildup, reducing DKA-related hospitalisations and healthcare costs.Standardising BrAce measurement techniques and sensitivity thresholds is essential to broaden clinical adoption.This review underscores the promise of nanotechnology-based breath analysis as a transformative tool for DKA management, with potential utility across varied ketotic conditions.